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Genetic analysis : principles, scope, and abjectives / John R.S. Fincham.

By: Material type: TextTextPublication details: Oxford ; Boston : Blackwell Scientific Publications, 1994.ISBN:
  • 0632036591
Subject(s): DDC classification:
  • 574.87322 20
LOC classification:
  • QH441
Contents:
Introduction: the expanding scope of genetics -- 1. Dissecting the genome using natural genetic systems. The eukaryotic system. Meiosis and the rules of classical genetics. Genetic analysis of bacteria and bacteriophage. Eukaryotic organelle genetics -- 2. From mutations to genes. Defining the gene by mutation and complementation. Mapping within the gene. The determination by genes of protein structure -- 3. The gene as DNA sequence. Characterization of DNA fragments. Cloning and cloning vectors. Screening DNA libraries for functional genes. Confirming the identity of cloned sequences. Simultaneous mutagenesis and gene tagging -- 4. The evolving concept of the gene. The gene as a cis-acting unit. The gene as a unit of translation. The gene as a unit of transcription. Processing of the primary transcript. The complex functions of promoters. Enhancers - the expanding frontiers of the gene. Restructured genes and edited messages -- 5. Analysis of the whole genome. Total DNA - quantities and patterns of complexity. The nature of repetitive DNA. Chromosome characterization by microscopy. Chromosome sorting - chromosome-specific probes and libraries. Comprehensive genetic mapping with molecular markers. From physical map to complete DNA sequence. DNA of the organelles. Conclusion: total analysis of genomes - what benefits to understanding? -- 6. Accounting for heritable variation. Molecular identification of mutations of strong effect. DNA sequence variation without phenotypic consequences. Quantitative variation and its heritability. Attributing heritable quantitative variation to chromosomal loci -- 7. Gene interactions and the genetic programme. Examples from the yeasts. Another level of control - RNA splicing in Drosophila sexual development. The emergence of morphological pattern. Selector genes in Drosophila and other organisms. Timing of gene expression - a function for introns? Stabilizing gene activity - epigenetic effects. Towards the complete description of the organism.
Holdings
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Two Week Loan Two Week Loan College Lane Learning Resources Centre Main Shelves 574.87322 FIN (Browse shelf(Opens below)) Available 4403902507
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Enhanced descriptions from Syndetics:

Introduction: the expanding scope of genetics -- 1. Dissecting the genome using natural genetic systems. The eukaryotic system. Meiosis and the rules of classical genetics. Genetic analysis of bacteria and bacteriophage. Eukaryotic organelle genetics -- 2. From mutations to genes. Defining the gene by mutation and complementation. Mapping within the gene. The determination by genes of protein structure -- 3. The gene as DNA sequence. Characterization of DNA fragments. Cloning and cloning vectors. Screening DNA libraries for functional genes. Confirming the identity of cloned sequences. Simultaneous mutagenesis and gene tagging -- 4. The evolving concept of the gene. The gene as a cis-acting unit. The gene as a unit of translation. The gene as a unit of transcription. Processing of the primary transcript. The complex functions of promoters. Enhancers - the expanding frontiers of the gene. Restructured genes and edited messages -- 5. Analysis of the whole genome. Total DNA - quantities and patterns of complexity. The nature of repetitive DNA. Chromosome characterization by microscopy. Chromosome sorting - chromosome-specific probes and libraries. Comprehensive genetic mapping with molecular markers. From physical map to complete DNA sequence. DNA of the organelles. Conclusion: total analysis of genomes - what benefits to understanding? -- 6. Accounting for heritable variation. Molecular identification of mutations of strong effect. DNA sequence variation without phenotypic consequences. Quantitative variation and its heritability. Attributing heritable quantitative variation to chromosomal loci -- 7. Gene interactions and the genetic programme. Examples from the yeasts. Another level of control - RNA splicing in Drosophila sexual development. The emergence of morphological pattern. Selector genes in Drosophila and other organisms. Timing of gene expression - a function for introns? Stabilizing gene activity - epigenetic effects. Towards the complete description of the organism.